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辣木君辣木君  2018-12-04 20:28 来源:辣木好 隐藏边栏 |   抢沙发  242 
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辣木抗糖尿病和抗氧化活性的实验研究「中英对照」 辣木文献

辣木抗糖尿病和抗氧化活性的实验研究

 

作者信息

印度斋浦尔拉贾斯坦大学动物学系高级研究中心生殖生理学科。Gupta R 1,Mathur M,Bajaj VK,Katariya P,Yadav S,Kamal R,Gupta RS。

 

概述

辣木(Moringa oleifera)是印度广泛种植的一种,是一种营养丰富的蔬菜,在治疗风湿病,毒性叮咬和微生物感染方面具有多种潜在用途。在本研究中,我们研究了辣木荚膜(MOMtE)甲醇提取物在链脲佐菌素(STZ)诱导的糖尿病白化大鼠中的抗糖尿病和抗氧化作用。

 

方法

用 150 或 300mg / kg MOMtE 处理糖尿病大鼠 21 天,并通过测量血清和胰腺组织中生化参数的变化来评估提取物的抗糖尿病作用。从 MOMtE 提取物中分离出两种植物成分,即槲皮素和山奈酚,并使用核磁共振和红外光谱测定它们的结构。

 

结果

MOMtE 治疗后糖尿病的进展明显减少。在治疗的大鼠中,两种剂量的 MOMtE 均诱导血清葡萄糖和一氧化氮的显着降低,同时伴随血清胰岛素和蛋白质水平的增加。此外,MOMtE 治疗增加了胰腺组织中的抗氧化剂水平,同时降低了硫代巴比妥酸反应性物质的水平。糖尿病大鼠胰腺的组织学检查显示β细胞的退行性变化; MOMtE 治疗显着逆转了对胰岛细胞的组织结构损伤。

 

结论

辣木对 STZ 诱导的糖尿病具有保护作用。MOMtE 表现出显著的抗糖尿病和抗氧化活性,并且可以从提取物中分离活性成分,用于将来的临床研究中的评估。

辣木抗糖尿病和抗氧化活性的实验研究「中英对照」 辣木文献

原文如下:

J Diabetes. 2012 Jun;4(2):164-71. doi: 10.1111/j.1753-0407.2011.00173.x.
Evaluation of antidiabetic and antioxidant activity of Moringa oleifera in experimental diabetes.
Gupta R1, Mathur M, Bajaj VK, Katariya P, Yadav S, Kamal R, Gupta RS.

 

Author information
Reproductive Physiology Section, Centre for Advanced Studies, Department of Zoology, University of Rajasthan, Jaipur, India. gupta_rs@hotmail.com
Abstract

 

BACKGROUND:
Moringa oleifera, a widely cultivated species in India, is an exceptionally nutritious vegetable with a variety of potential uses in treating rheumatism, venomous bites, and microbial infections. In the present study, we investigated the antidiabetic and antioxidant effects of methanol extracts of M. oleifera pods (MOMtE) in streptozotocin (STZ)-induced diabetic albino rats.

 

METHODS:
Diabetic rats were treated with 150 or 300 mg/kg MOMtE for 21 days and the antidiabetic effects of the extract were evaluated by measuring changes in biochemical parameters in the serum and pancreatic tissue. Two phytoconstituents, namely quercetin and kaempferol, were isolated from the MOMtE extract and their structures were determined using nuclear magnetic resonance and infrared spectroscopy.

 

RESULTS:
The progression of diabetes was significantly reduced after MOMtE treatment. In treated rats, both doses of MOMtE induced a significant reduction in serum glucose and nitric oxide, with concomitant increases in serum insulin and protein levels. Furthermore, MOMtE treatment increased antioxidant levels in pancreatic tissue, with concomitant decreases in levels of thiobarbituric acid-reactive substances. Histologic examination of the pancreas from diabetic rats showed degenerative changes in β-cells; MOMtE treatment significantly reversed the histoarchitectural damage to the islets cells.

 

CONCLUSION:
In conclusion, M. oleifera exerts protective effects against STZ-induced diabetes. The MOMtE exhibited significant antidiabetic and antioxidant activity and active constituents may be isolated from the extract for evaluation in future clinical studies.

 

© 2011 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and Blackwell Publishing Asia Pty Ltd.

 

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